This means you can feel safe in knowing that, even if you can’t uninstall Avast using Windows Settings, you should be safe to use the Avast uninstall utility to remove it instead. If this doesn’t work (or you just don’t trust Avast at this stage), then there are third-party alternatives you can try instead. If your Antivirus is still running in Safe Mode, Avast will warn you that an attempt to remove it is in progress. Allow this by clicking Yes in.